Losartan vs. Lisinopril: Similarities and Differences

Discover the key differences and similarities between Losartan and Lisinopril, two common medications for managing high blood pressure and heart conditions.

9. Jul 2024
Losartan vs. Lisinopril: Similarities and Differences

When it comes to managing high blood pressure (hypertension) and heart conditions, doctors often prescribe medications known as ACE inhibitors and ARBs. Two of the most common medications in these categories are Lisinopril and Losartan. Understanding their similarities and differences can help you make informed decisions about your treatment.


Purpose: Both Losartan and Lisinopril are primarily used to treat high blood pressure. They can also help protect the kidneys in patients with diabetes and reduce the risk of stroke.

Effectiveness: Both medications are effective in lowering blood pressure and can help in the management of heart failure. They work by relaxing blood vessels, allowing blood to flow more easily.

Kidney Protection: Both drugs offer protective benefits for the kidneys, especially in patients with diabetes. This makes them valuable options for managing diabetic nephropathy (kidney damage caused by diabetes).

Side Effects: Common side effects for both medications include dizziness, headaches, and fatigue. These usually occur because the medications lower blood pressure, which can sometimes cause these symptoms as your body adjusts.


Drug Class:

  • Lisinopril is an ACE inhibitor (Angiotensin-Converting Enzyme inhibitor). It works by blocking the formation of angiotensin II, a substance that narrows blood vessels.
  • Losartan is an ARB (Angiotensin II Receptor Blocker). Instead of blocking the formation of angiotensin II, it blocks its action on blood vessels.

Side Effects:

  • Lisinopril can cause a persistent dry cough in some people. This is a well-known side effect of ACE inhibitors.
  • Losartan does not commonly cause this cough. It’s often prescribed to patients who experience this side effect with Lisinopril.

Usage in Specific Conditions:

  • Lisinopril is often chosen for initial treatment in heart failure and after a heart attack due to its beneficial effects on heart remodeling and survival.
  • Losartan is sometimes preferred in patients with certain types of chronic kidney disease, especially those who cannot tolerate ACE inhibitors due to the cough.
  • Potassium Levels: Both medications can increase potassium levels in the blood, but the risk might be slightly higher with Losartan. It’s important to monitor potassium levels and kidney function regularly while on these medications.

Dosage Forms and Frequency:

  • Lisinopril is typically taken once daily and is available in tablet form.
  • Losartan is also usually taken once daily, but it comes in both tablet form and a combination form with hydrochlorothiazide, a diuretic.

Which One is Right for You?

The choice between Losartan and Lisinopril largely depends on your individual health needs and how you tolerate each medication. Your doctor will consider factors such as your medical history, any other conditions you have, and how you respond to the medication.


Both Losartan and Lisinopril are effective medications for managing high blood pressure and protecting your heart and kidneys. While they have many similarities, their differences in drug class, side effects, and specific uses make it important to work with your doctor to determine which one is best for you. Always follow your healthcare provider’s advice and report any side effects or concerns you may have.

Note - We can not guarantee that the information on this page is 100% correct. Some article is created with help of AI.


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Rishabh Sinha
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